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Clinical picture: SCT (Stem Cell Transplantation and Cellular Therapies)

Trial: HOVON-associated Innate allo-SCT

1. Overview
Study details
2. Patient eligibility criteria
3. Registration (& randomization) of patients
4. Participating parties
5. Participating sites
6. Instruction videos
7. Download documentation / forms

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Innate allo-SCT news

Mainz will be the second center that is participating in the Innate allo-SCT study.


Please find the protocol behind the login.

1. Overview


Towards a novel immune therapy platform with an innate allogeneic haematopoietic stem cell transplantation in patients with haematological malignancies.



Study details

Type of study

Prospective Phase II study

Target number of patients


Study objectives

Primary Objective:
To implement an T-cell depleted stem cell transplantation as low-GVHD platform in order to increase the number of patients eligible for further immune interventions from day 100.
Secondary Objective:
To address all other clinical transplantation-related parameters and immunological reconstitution after an T-cell depleted stem cell transplantation.

2. Patient eligibility criteria

Inclusion criteria

Adults (> 18 years)
Haematological malignancies eligible for allo-SCT according to the policy of the local centre
WHO performance status ≤ 2
Written informed consent

Exclusion criteria

Relapse of allo-SCT within 5 months after allo-SCT
Bilirubin and/or transaminases > 2.5 x normal value
Creatinine clearance < 40 ml/min
Cardiac dysfunction as defined by:
- Unstable angina
- Unstable cardiac arrhythmias
Active, uncontrolled infection

3. Registration (& randomization) of patients


Register new patient through UMCU

Registration criteria

The following information will be requested:

inclusion and exclusion criteria

4. Participating parties

Principal investigator

J. Kuball, MD Professor (

Coordinating investigator(s)

M.A. de Witte , MD, PhD
L. van de Wagen, MD

Other functions

Processing of cellular products:
I.C.M. Slaper-Cortenbach (

5. Participating sites

6. Instruction videos

7. Download documentation / forms


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