Lymphoma Associated studies

Open trials

Short name BRUIN MCL 312
Study title A Phase 3 Open-Label, Randomized Study of LOXO-305 versus Investigator Choice of BTK Inhibitor in Patients with Previously Treated BTK Inhibitor Naïve Mantle Cell Lymphoma.
Status Open in ErasmusMC (Rotterdam), Bravis hospital (Roosendaal), Hagaziekenhuis (Den Haag)
Soon to be opened in Spaarneziekenhuis (Haarlem).
mediocation Ibrutinib versus LOXO-305 (pirtobrutinib)
Population Recurrence or relapse Mantle cell lymphoma, previously untreated with BTK inhibitor
Study docs Eligibility
Short name ZUMA-2 cohort 3
Study title A Phase 2 Multicenter Study Evaluating the Efficacy of KTE-X19 in Subjects with Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)
Status Open in AUMC (AMC), EMC & UMCG
Medication KTE-X19
Population r/r MCL BTKi-naive (i.e. Ibrutinib, Acalabrutinib)
Study docs Subject eligibility
Short name EPCORE DLBCL-1
Study title A randomized phase 3 trial of subcutaneous epcoritamab versus investigator choice chemotherapy (R-Gem/Ox or R-benda) in relapsed/ refractory DLBCL
Status Open
Study info

rr DLBCL (de novo or tFL); HGBCL (de novo or tFL); FL grade 3b.
After or not eligible for ASCT (due to age, performance, co-morbidity or insufficient response)

Participants

Open at Erasmus MC (p.lugtenburg@erasmusmc.nl)
The study will open soon in 11 other HOVON centers

Study docs Eligibility checklist
Short name Mangrove studie (Beigene-3111-306)
Study title A Phase 3 Randomized, Open-Label, Multicenter Study Comparing Zanubrutinib (BGB-3111) plus Rituximab Versus Bendamustine plus Rituximab in Patients with Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
Status Open
Participants

Erasmus MC Rotterdam – J Doorduijn
Albert Schweitzer Ziekenhuis Dordrecht – E de Jongh
Hagaziekenhuis den Haag – L Bohmer
ADRZ Goes – Y Bilgin
UMCG Groningen – T v Meerten
Spaarnegasthuis Hoofddorp –A Beeker

Study docs Eligibility
Short name HD21
Study title Treatment optimization trial in the first line treatment of adv stage HL: comparison of 4-6 cycles of esc BEACOPP with 4-6 cycles of BrECADD
Status Open
Participants AmsterdamUMC - VUmc- JM Zijlstra
MeanderMC – JC Regelink
Jeroen Bosch ziekenhuis- H Pruijt
ADR ziekenhuis Goes- S Kuipers
OLVG A’dam – A. Gerrits
WFG Hoorn- C Klerk
Haga ziekenhuis- L Bohmer
LUMC- H Veelken
Anthonius ziekenhuis- M Sohne
Study docs Flow + eligibility
Protocol

 

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