CLL Associated studies

 Open trials

Short name CELESTIAL-TNCLL study
Study title A Phase 3, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Patients With Previously Untreated Chronic Lymphocytic Leukemia.
Status Open
Reference Clinicaltrials.gov: NCT06073821
Population

Treatment-naïve (TN) adults with confirmed diagnosis of CLL which requires treatment, 18 Years and older   (Adult, Older Adult)

Participants

Martini Ziekenhuis - Groningen - Schreurs
Ikazia Ziekenhuis - Rotterdam - de Boer
Hagaziekenhuis - Den Haag - Kersting
Albert Schweitzer hospital - Dordrecht - Levin
Meander MC - Amersfoort - Regelink
Maasstad Ziekenhuis - Rotterdam - Sandberg
Franciscus Gasthuis & Vlietland - Schiedam - Boiten
Reinier de Graaf Gasthuis - Delft - Posthuma
Noordwest Ziekenhuisgroep locatie Alkmaar - Alkmaar - Visser
Elisabeth-TweeSteden Ziekenhuis (ETZ) - Tilburg - Droogendijk
AmsterdamUMC - Amsterdam - Kater
Flevoziekenhuis - Almere - Kater

Study docs  Eligibility criteria
Short name M18-803 T-PLL
Study title A Prospective, Open-Label, Single-Arm, Phase 2, Multicenter Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Subjects with T-Cell Prolymphocytic Leukemia
Reference Clinicaltrials.gov: NCT03873493
Status Open
Participants M. Bellido, Universitair Medisch Centrum, Groningen; m.bellido@umcg.nl
L. Tick, Maxima Medisch Centrum, Eindhoven; l.Tick@mmc.nl
Study docs Eligibility criteria
Short name ACE-CL-311
Study title A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in Combination with Venetoclax with and without Obinutuzumab Compared to Investigator’s Choice of Chemoimmunotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia Without del(17p) or TP53 Mutation.
Reference Clinicaltrials.gov: NCT04008706
Status Open
Participants AmsterdamUMC - location AMC – Arnon Kater
Flevoziekenhuis – Koen de Heer
Study docs Flow + Eligibility criteria
Short name ACE-CL-312
Study title A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects with Chronic Lymphocytic Leukemia
Reference Clinicaltrials.gov: NCT04008706
Status Open only for patients with prior BTKi therapy (Cohort3) (Other cohorts: Treatment-naive patients and enrollment of patients with Relapsed/Refractory disease are complete)
Participants Open in:
Universitair Medisch Centrum Utrecht (Utrecht) Rogier Mous (r.mous@umcutrecht.nl)
Will also be opened in:
Albert Schweitzer Ziekenhuis (Dordrecht), Mark-David Levin
HagaZiekenhuis (Den Haag), Sabina Kersting
Rijnstate Ziekenhuis (Arnhem) Ellen vd Spek
Isala Klinieken (Zwolle), Ellen Dompeling
Study docs Flow + Eligibility criteria
Up