CLL Associated studies
Open trials
| Short name | LAVA |
| Study title | A phase 1 and 2a open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and antitumor activity of LAVA-051 in patients with relapsed or refractory CD1d-positive chronic lymphocytic leukemia, multiple myeloma or acute myeloid leukemia |
| Status | Open |
| Information |
https://www.hematologie-wijzer.nl/home/studieprotocollen/cll |
| Participants |
Amsterdam UMC - AMC (A. Kater) |
| Short name | M18-803 T-PLL |
| Study title | A Prospective, Open-Label, Single-Arm, Phase 2, Multicenter Study Evaluating the Efficacy of Venetoclax Plus Ibrutinib in Subjects with T-Cell Prolymphocytic Leukemia |
| Reference | Clinicaltrials.gov: NCT03873493 |
| Status | Open |
| Participants | M. Bellido, Universitair Medisch Centrum, Groningen; m.bellido@umcg.nl L. Tick, Maxima Medisch Centrum, Eindhoven; l.Tick@mmc.nl |
| Study docs | Eligibility criteria |
| Short name | ACE-CL-311 |
| Study title | A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in Combination with Venetoclax with and without Obinutuzumab Compared to Investigator’s Choice of Chemoimmunotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia Without del(17p) or TP53 Mutation. |
| Reference | Clinicaltrials.gov: NCT04008706 |
| Status | Open |
| Participants | AmsterdamUMC - location AMC – Arnon Kater Flevoziekenhuis – Koen de Heer |
| Study docs | Flow + Eligibility criteria |
| Short name | ACE-CL-312 |
| Study title | A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects with Chronic Lymphocytic Leukemia |
| Reference | Clinicaltrials.gov: NCT04008706 |
| Status | Open only for patients with prior BTKi therapy (Cohort3) (Other cohorts: Treatment-naive patients and enrollment of patients with Relapsed/Refractory disease are complete) |
| Participants | Open in: Universitair Medisch Centrum Utrecht (Utrecht) Rogier Mous (r.mous@umcutrecht.nl) Will also be opened in: Albert Schweitzer Ziekenhuis (Dordrecht), Mark-David Levin HagaZiekenhuis (Den Haag), Sabina Kersting Rijnstate Ziekenhuis (Arnhem) Ellen vd Spek Isala Klinieken (Zwolle), Ellen Dompeling |
| Study docs | Flow + Eligibility criteria |