HOVON HO71
Archived
Main info
- Identifier:
- HOVON 71 ALL
- Sponsor:
- HOVON
- Included patients:
-
60
- Active sites:
-
21(of 21)
- Title:
Treatment of acute lymphoblastic leukemia (ALL) in adults age 40 - 70 years inclusive with chemotherapy including a pre-induction course for rapid tumor load reduction and prolonged maintenance chemotherapy.
Timeline
Scheduled
Actual
2005
21 Oct
Activated
2008
03 Jan
CloseoutInProgressLastPtOutActualStart
2018
03 Jan
Archived
Flow

Details
- Phase:
- Prospective Phase II study
- Monitoring Type:
- Objectives:
Eligibility
- Inclusion Criteria:
- Age 40 - 70 years inclusive;
- Primary previously untreated ALL;
- WHO performance status 0, 1, or 2 (appendix C);
- Negative pregnancy test at inclusion if applicable;
- Written informed consent.
- Exclusion Criteria:
- Mature B-cell ALL;
- Acute undifferentiated leukemia (AUL);
- Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease);
- Severe pulmonary dysfunction (CTCAE grade III-IV);
- Severe neurological or psychiatric disease;
- Significant hepatic dysfunction (serum bilirubin or transaminases >=3 times normal level) except when caused by leukemic infiltration;
- Significant renal dysfunction (serum creatinin >=3 times normal level after rehydration and correction of hyperuricemia);
- History of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma;
- History of anthracycline use exceeding a cumulative dose of 300 mg/m2 doxorubicin (or its biological equivalent);
- Active, uncontrolled infections;
- Patients known to be HIV-positive;
- Patient is a lactating woman;
- Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
Participating Sites
Site
21 results
Order by
Accrual rate
Activation date
NL-Rotterdam-EMCDANIEL
15
NL-Rotterdam-ERASMUSMC
7
NL-Maastricht-MUMC
5
NL-Utrecht-UMCUTRECHT
5
NL-Nijmegen-RADBOUDUMC
4
NL-Groningen-UMCG
4
NL-Amsterdam-AMC
4
NL-Amsterdam-VUMC
3
NL-Enschede-MST
2
NL-Zwolle-ISALA
2
NL-Arnhem-RIJNSTATE
2
NL-Leiden-LUMC
2
BE-Antwerpen-ZNASTUIVENBERG
1
NL-Den Haag-HAGA
1
BE-Leuven-UZLEUVEN
1
BE-Roeselare-AZDELTA
1
NL-Amersfoort-MEANDERMC
1
NL-Nieuwegein-ANTONIUS
NL-Amsterdam-OLVG
BE-Brugge-AZBRUGGE
NL-Hilversum-TERGOOI