HOVON HO95 MM

Closed
Go to eCRF: EMN eCRF

Main info

Identifier:
HOVON 95 MM / EMN02
Sponsor:
HOVON
Working group party:
Myeloma
Age:
18-65
Stage:
1st Line
Echelon:
Level D
Included patients:
1503
(of 1500)
Active sites:
243
(of 189)
Title:

A randomized phase III study to compare Bortezomib, Melphalan, Prednisone (VMP) with High Dose Melphalan followed by Bortezomib, Lenalidomide, Dexamethasone (VRD) consolidation and Lenalidomide maintenance in patients with newly diagnosed multiple myeloma.

Timeline

Scheduled
Actual
2010
03 May
EC Approval
2010
02 Nov
EC Approval
2011
21 Jan
Activated
2011
21 Jan
First Site
2011
14 Feb
FPI
2014
19 Aug
ClosedForInclusionActualStart
2019
04 Jan
Opportunity
2019
05 Mar
Endpoint Analysis

News

  • For data management go to the EMN website: (http://www.mm-sen.net/)
  • Sampling (at relapse/progression to central lab) IMPORTANT: it is not possible to ship material on a Friday, Saturday or Sunday. If your hospital routinely has multiple myeloma patient appointments for obtaining clinical samples on these days, please inform the PI and please change the planning. Seeing patients for MM biomaterial sampling on a Friday or on the weekend is in direct conflict with participating in a clinical trial such as this one.
  • The study has been closed for inclusion on 15APR14, many thanks for your precious collaboration to make this into a highly successfull study! Of course patients included can still receive maintenance treatment.
  • AM8 (protocol version 7 dd 04DEC2019) has been approved in the Netherlands. Maintenance therapy until progression; data collection during 10 years instead of 7 years.
  • AM5 (protocol version 6 dd 06MAY14) has been approved. Change in treatment schedule Lenalidomide during maintenance from 28 days to 21 days followed by 7 days rest. Further information can be found in the summery of changes form.
  • AM4 (protocol version 5 dd 15JAN13) has been approved. The Lenalidomide doses 2.5mg and 7.5mg has been deleted from the protocol.
  • AM3 has been approved, the main changes were 4VCD cycles and Velcade s.c. Please find more information in the summary of changes documents.
  • AM2 has been approved, this concerns the new packaging of Lenalidomide. The new batch will not have vials with capsules, but has blisters with separately packed capsules in a press-through sheet.
  • AM1 concerned the addition of the Belgium site ZNA Stuivenberg and the integrations of adverse events of lenalidomide including the risk of 2nd cancer
  • Updated documents:

28MAY2020: Updated CRF instructions
14JAN2020: Updated SAE form with new fax number
27MAR2017: Updated Lenalidomide accountability form, to add 'Returned by patient' as option, so that this part of the accountability is not forgotten.
14DEC15: Updated Pharmacy information letter to reflect usage of IDOS + uploade IDOS instructions below other documents
18NOV15: Renewed drug order form for Lenalidomide
29SEP14: Deletion of subject enrollement list to make room for QoL declaration form (please note, this can only be used by Dutch sites.
30JUL14: Deletion of Registrate Enroll and Randomization CRF's_26NOV12, replacement by separate Randomization 1 and Randomization 2 CRF
16JUL14: New protocol (version 6) + summery of changes, updated portfolio regarding EC and CA approval for the Netherlands
15MAY14: New Statement of expenses form for Dutch sites for QoL
14MAY14: New Dutch WMO insurance (enddate of insurance changed to 2018)
08APR14: New FAQ sheet, correctie versie 20MAR14
11NOV13: New Pharmacy information letter dated 11NOV13
21OCT13: New FAQ sheet
19JUN13: New Pharmacy information letter dated 19JUN13
03SEP13: New portfolios created for BE (site documents, EC and CA portfolio)
11JUN13: New Insurance policy BE (valid util 31DEC13)
05FEB13: New Pharmacy information letter dated 05FEB13
22JAN13: New Registrate Enroll and Randomization CRFs_26NOV12.pdf
07DEC12: New documents regarding AM3
- Protocol
- Protocol amendment(s)
- Patient Information & IC form (NL)
- Patient Information & IC form (EN)
- PI & ICF amendment(s)
- CCMO response
- MEC approval
- Signature page of protocol
- HO95 ICF template asymptomatic patients nl v2 13jun12 cc
- HO95 ICF asymptomatic patients summary of changes am3 dd 20jun12
- HO95 ICF template extra sampling nl v1 13jun12
- EMN02 HO95 ICF alloSCT substudy v2 dd 25jun12 cc
- HO95 ICF template pet scan substudy nl v1 13jun12
- HO95 Flowchart_12DEC12
28OCT12: SAE form
16OCT12: New FAQ sheet
16JUL12: CRF instructions
19JUN12: SAE instuctions
29MAY12: New pharmacy information letter (includes also the option to order Lenalidomide per quarter of the year - was previously only accepted for Bortezomib)
29MAR12: 'onderzoeksverklaring' to be used for Dutch sites that did not perform their local submission yet
16MAR12: New declaration form of expenses (previous version was lacking contact information)
01MAR12: New pharmacy information letter (reflects the adjusted Lenalidomide study medication procedure)
16FEB12: EC Approval (portfolio) with AM2 approval
25NOV11: EMN02 HO95 eCRF printscreen versions_19AUG11.pdf
25NOV11: New version of EMN02 HO95_Registrate, Enroll and Randomization CRFs_25OCT11.pdf
27JUL11: HO95_creation of subaccounts_07JUL11.pdf (new)
27JUL11: EMN02 HO95 eCRF printscreen versions_13JUL11.pdf (new)
27JUL11: New version of EMN02 HO95_Registrate, Enroll and Randomization CRFs_07JUL11_clean version.pdf (replaces the one dated 28APR11)
16JUN11: New Verpleegkundig protocol dated 16JUN11 (replaces the one dated 28APR11)
15JUN11: New Pharmacy information letter dated 07JUN11 (replaces the one dated 19APR11)

Flow

Flow

Details

Phase:
Prospective randomized Phase III study
Monitoring Type:
Site Evaluation Visit
Objectives:

Primary

  • Efficacy of FCM in correction of ID (TSAT >=20%)
  • Impact of FCM on quality of life (EORTC QLQ-C30)

Secondary
Impact of FCM on:

  • Haemoglobin levels during induction therapy
  • Number of stem cells collected
  • Transfusion rate during induction
  • Transfusion rate after stem cell transplantation (<21 days)
  • Response to VCD induction chemotherapy
  • Toxicity

Eligibility

Inclusion Criteria:
  • Patients with a confirmed diagnosis of symptomatic multiple myeloma stage I to III according to the International Staging System ISS (see appendix A), i.e. at least one of the CRAB criteria should be present;
  • Measurable disease as defined by the presence of M-protein in serum or urine (serum Mproteïn > 10 g/l or urine M-proteïn > 200 mg/24 hours or abnormal FLC ratio with involved free light chain (FLC) > 100 mg/l) or proven plasmacytoma by biopsy;
  • Age 18-65 years inclusive;
  • WHO performance status 0-3 (WHO=3 is allowed only when caused by MM and not by comorbid conditions) (see appendix D);
  • Negative pregnancy test at inclusion if applicable;
  • Written informed consent.

Inclusion criteria for randomization 1:

  • WHO performance 0-2;
  • Bilirubin and transaminases < 2.5 times the upper limit of normal values;
  • A suitable stem cell graft containing at least 4 x 10^6 CD34+ cells/kg (or according to national guidelines).

Inclusion criteria for randomization 2:

  • Bilirubin and transaminases < 2.5 times the upper limit of normal values;
  • ANC ≥ 0.5 x 10^9/l and platelets > 20 x 10^9/l;
  • Patient is able to adhere to the requirements of the Lenalidomide Pregnancy Prevention Risk Management Plan.
Exclusion Criteria:
  • Known intolerance of Boron;
  • Systemic AL amyloidosis;
  • Primary Plasmacell Leukemia;
  • Non-secretory MM;
  • Previous chemotherapy or radiotherapy except local radiotherapy in case of local myeloma progression or corticosteroids maximum 5 days for symptom control;
  • Severe cardiac dysfunction (NYHA classification II-IV, see appendix E);
  • Significant hepatic dysfunction (serum bilirubin ≥ 30 μmol/l or transaminases ≥ 2.5 times normal level), unless related to myeloma;
  • Patients with GFR <15 ml/min,
  • Patients known to be HIV-positive;
  • Patients with active, uncontrolled infections;
  • Patients with neuropathy, CTC grade 2 or higher;
  • Patients with a history of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma;
  • Patients who are not willing or capable to use adequate contraception during the therapy (all men, all pre-menopausal women);
  • Lactating women.

Exclusion criteria for randomization 1:

  • Severe pulmonary, neurologic, or psychiatric disease;
  • CTCAE grade 3-4 polyneuropathy during Bortezomib treatment;
  • Allogeneic Stem Cell Transplantation (Allo SCT) planned;
  • Progressive disease.

Exclusion criteria for randomization 2:

  • Progressive disease;
  • Neuropathy, except CTCAE grade 1;
  • CTCAE grade 3-4 polyneuropathy during Bortezomib treatment.

Registration Details

The patient should be registered immediately after diagnosis and before the start of chemotherapy.
Patients will be registered at the EMN Data Center by web http://www.mm-sen.net. Investigators who do not have an account yet should register at this website to obtain an account.
The following information will be requested at registration:

  • Institution name
  • Name of responsible investigator
  • Date of birth
  • Date of informed consent
  • Date of sample shipment (optional)
  • Date of diagnosis of multiple myeloma
  • Criteria for measurable disease
  • Serum β2-microglobulin
  • Serum albumin
  • Eligibility criteria

Final analysis VRD randomization (Q2/Q3-2020)

Go to eCRF: EMN eCRF

Participating Sites

Ziekenhuizen die deelnemen aan het onderzoek staan benoemd op de HOVON website bij het onderzoek. Het kan zijn dat uw ziekenhuis niet genoemd wordt, maar wel aan het onderzoek deelneemt. Informeer hiernaar bij uw arts.

Site
243 results
Order by
Accrual rate
Activation date
IT-Torino-CITTADELLASALUTE
69
09 Jan 2012
TR-Ankara-CEBECIHASTANESI
53
11 Sep 2012
IT-Roma-SAPIENZA
49
24 Aug 2011
IT-Bologna-MALPHIGI
44
18 Mar 2011
GR-Athens-ALEXANDRA
37
24 Jul 2012
IT-Catania-FERRAROTTO
32
23 Feb 2012
IT-Udine-POLICLINCOUDINE
29
06 Dec 2011
IT-Genova-SANMARTINOG
29
13 Jul 2011
IT-Milano-ISTITUTOTUMORI
25
10 Jan 2012
IT-Bergamo-RIUNITIBERGAMO
24
12 Oct 2011
CZ-Hradec Kralove-FNHK
23
06 Jun 2012
SE-Lund-SUH
22
11 Jun 2012
IT-Reggio Emilia-ASMN
22
19 Oct 2011
CZ-Brno-UHBRNO
21
02 Apr 2012
IT-Brescia-SPEDALICIVILI
21
16 Aug 2011
NL-Den Haag-HAGA
20
21 Apr 2011
IT-Cuneo-CROCEECARLE
19
25 Nov 2011
IT-Ancona-UMBERTOA
18
28 Nov 2011
NL-Nijmegen-RADBOUDUMC
18
09 May 2011
IT-Reggio Calabria-BIANCHIMORELLI
18
08 Jun 2011
IT-Perugia-OSPEDALEPERUGIA
18
11 Nov 2011
IT-Terni-AOSPTERNI
17
30 May 2011
DK-Aarhus N-AUH
17
30 May 2012
IT-Padova-UDSPADOVA
17
07 Oct 2011
IT-Torino-MOLINETTE
16
09 Jan 2012
IT-Mestre-DELLANGELO
16
19 Jun 2012
NL-Amsterdam-VUMC
16
08 Nov 2011
NL-Maastricht-MUMC
15
08 Nov 2011
NL-Rotterdam-ERASMUSMC
15
01 Feb 2011
NL-Dordrecht-ASZ
15
20 Sep 2011
AT-Vienna-WILHELMINEN
14
05 Apr 2012
IT-Pescara-AUSLPESCARA
14
03 May 2012
CZ-Ostrava-Poruba-FNO
13
29 Aug 2012
NL-Breda-AMPHIA
13
28 Feb 2011
CZ-Olomouc-FNOL
13
11 Dec 2012
BE-Antwerpen-ZNASTUIVENBERG
13
08 Feb 2011
NL-Leiden-LUMC
12
04 Apr 2011
NL-Goes-ADRZ
12
14 Dec 2011
NL-Tilburg-ETZ
12
10 Jan 2012
IT-Roma-SANTEUGENIO
12
05 Feb 2012
DK-Copenhagen-RIGSHOSPITALET
11
03 Feb 2012
CH-St. Gallen-KSSG
11
17 Aug 2012
NL-Utrecht-UMCUTRECHT
11
09 Nov 2011
IT-Bari-POLICLINICODIBARI
11
SE-Goteborg-SAHLGRENSKA
11
22 Jun 2012
IT-Nuoro-SANFRANCESCO
11
23 Nov 2011
NL-Zwolle-ISALA
11
03 Aug 2011
NL-Nijmegen-CWZ
11
24 Mar 2011
IT-Milano-NIGUARDA
11
13 Sep 2011
IT-Avellino-AOSGMOSCATI
10
16 Aug 2011
IT-Cosenza CS-ANNUNZIATA
10
13 Jun 2011
IT-Roma-SANCAMILLOROMA
10
10 Jul 2012
NL-Hoorn-DIJKLANDERHOORN
9
24 Feb 2012
IT-Ravenna-SANTAMARIADELLECROCI
9
DK-Aalborg-AALBORGUH
9
26 Mar 2012
NL-Rotterdam-MAASSTADZIEKENHUIS
9
04 Apr 2011
IT-Milano-HUMANITAS
9
12 Jul 2011
IT-Modena-POLICLINICOMODENA
8
01 Mar 2012
DK-Herlev-HERLEV
8
19 Mar 2013
CH-Luzern-LUKS
8
19 Jun 2012
NL-Amsterdam-OLVG
8
01 Jul 2011
IT-Trieste-MAGGIORETRIESTE
8
12 Jul 2012
NL-Nieuwegein-ANTONIUS
8
02 Feb 2012
NL-Schiedam-FRANCISCUSVLIETLAND
8
13 Dec 2011
NL-Enschede-MST
8
19 Sep 2011
IT-Cagliari-BINAGLI
8
28 May 2012
IT-Rionero in Vulture (Potenza)-IRCCSCROB
7
12 Jul 2011
NL-Arnhem-RIJNSTATE
7
18 Dec 2012
NL-Deventer-DZ
7
22 Mar 2011
NL-Alkmaar-NWZ
7
04 Apr 2012
IT-Alessandria-ANTONIOBIAGIO
7
26 Mar 2012
NL-Amsterdam-AMC
7
05 Jun 2012
IT-Bolzano-BOLZANO
7
03 Apr 2012
IT-Meldola-IRSTEMR
7
18 Jan 2012
IT-Messina-POLIME
7
06 Jul 2011
DK-Roskilde-ROSKILDE
6
11 Feb 2013
NL-Groningen-UMCG
6
19 Mar 2012
CZ-Plzen-FNPLZEN
6
06 Mar 2013
NL-Hoofddorp-SPAARNEGASTHUIS
6
21 Nov 2011
BE-Turnhout-AZSTELISABETH
6
12 Jul 2011
IT-Candiolo-IRCC
6
16 Apr 2012
IT-Rimini-INFERMI
6
15 Dec 2011
NL-Winterswijk-SKBWINTERSWIJK
6
24 Nov 2011
IT-Roma-REGINAELENA
6
17 Jan 2012
NO-Oslo-OSLOUH
6
07 Dec 2012
NL-Heerlen-ATRIUMMC
6
01 Jul 2011
NL-Amsterdam-SLAZLUCAS
5
13 Mar 2012
TR-Adana-BASKENT
5
22 Feb 2013
IT-Pavia-MAUGERI
5
06 Jul 2011
AU-Melbourne-ALFRED
5
11 Oct 2013
PT-Lisboa-IPOLISBOA
5
03 Dec 2013
BE-Liege-CHRCITADELLE
5
08 Mar 2011
IT-Palermo-PAOLOGIACCONE
5
24 Jan 2012
NO-Rud-BAERUM
5
08 Jan 2013
NO-Trondheim-STOLAV
5
15 Jun 2012
CH-Bern-INSEL
5
07 Aug 2012
IT-Roma-SANGIOVANNIROMA
5
16 Feb 2012
NL-Ede-ZGV
5
16 Jan 2013
NL-Amersfoort-MEANDERMC
5
06 May 2013
AU-Sydney-NEPEAN
4
03 Oct 2013
NO-Tromsø-NORTHNOORWEGEN
4
07 Jan 2013
SE-Boras-SASBORAS
4
15 Oct 2012
IT-Foggia-RIUNITIFOGGIA
4
19 Dec 2011
IT-Roma-UCBIOMEDICO
4
27 Oct 2011
IT-Tricase (Lecce)-PANICO
4
07 Sep 2011
AU-Canberra-CANBERRAHOSPITAL
4
08 Oct 2013
CZ-Praag 2-VFN
4
02 Jan 2013
AT-Linz-ORDENSKLINIKUM
4
31 Jul 2012
NL-Capelle a/d IJssel-YSL
4
25 Nov 2011
SE-Luleå-SUNDERBY
4
06 Mar 2013
NL-Uden-BERNHOVEN
4
27 Mar 2013
NL-Eindhoven-MAXIMAMC
4
23 May 2012
AU-Brisbane-PAH
4
16 Oct 2013
NL-Hilversum-TERGOOI
4
30 May 2012
NL-Roosendaal-BRAVIS
4
11 Oct 2011
NL-Delft-RDGG
4
14 Dec 2011
IT-Napoli-FEDERICO
4
22 Dec 2011
NL-Gouda-GROENEHART
4
16 Jan 2013
CH-Liestal-KSBL
3
28 Aug 2012
SE-Linköping-REGIONOSTERGOTLAND
3
20 Jun 2012
DK-Odense-OUH
3
19 Sep 2012
NL-Venlo-VIECURI
3
10 Jul 2013
NL-Den Bosch-JBZ
3
17 Oct 2011
NO-Forde-HELSEFORDE
3
21 Dec 2012
NO-Stavanger-HELSESTAVANGER
3
07 Feb 2013
NL-Rotterdam-SFG
3
29 Sep 2011
CH-Aarau-KSA
3
28 Aug 2012
IT-Latina-POLOPONTINO
3
08 Oct 2012
CH-Bellinzona-IOSI
3
25 Sep 2012
IT-Napoli-CARDARELLI
3
17 Aug 2011
NL-Zaandam-ZAANSMC
3
10 Apr 2013
NL-Rotterdam-IKAZIA
3
27 Mar 2012
NL-Helmond-ELKERLIEK
3
27 Aug 2012
SE-Uddevalla-VGREGION
3
27 Sep 2012
NO-Alesund-HELSEMR
3
02 Oct 2012
IT-Lecco-ALESSANDROMANZONI
3
14 May 2012
IT-Siena-SCLAVO
3
09 May 2012
CH-Basel-USB
3
13 Aug 2012
SE-Umeå-VASTERBOTTEN
3
26 Oct 2012
NL-Roermond-LZR
3
13 Feb 2013
IT-Roma-OSPEDALESANTANDREA
2
18 May 2012
BE-Haine-Saint-Paul-JOLIMONT
2
02 Mar 2011
NL-Apeldoorn-GELREAPELDOORN
2
19 Feb 2013
NL-Gorinchem-BEATRIX
2
10 Apr 2012
CH-Chur-KSGR
2
17 Aug 2012
AT-Salzburg-SALK
2
24 May 2012
IS-Reykjavik-LANDSPITALI
2
08 Jul 2013
IT-Brindisi-PERRINO
2
17 Feb 2014
TR-Kayseri-ERCIYES
2
19 Sep 2013
BE-Antwerpen-ZNAMIDDELHEIM
2
25 Jan 2011
CH-Zürich-USZ
2
17 Aug 2012
IT-Gallarate VA-ANTONIOABATE
1
13 Dec 2011
CH-Thun-STSAGSPITALSTSAG
1
13 Aug 2012
SE-Örebro-OREBROUH
1
20 Nov 2012
BE-Tournai-CHWAPI
1
04 Dec 2013
NL-Beverwijk-RKZ
1
04 Jun 2012
NL-Haarlem-SPAARNEHAARLEM
1
28 Nov 2013
SE-Falun-REGIONDALARNA
1
20 Jun 2012
NL-Drachten-NIJSMELLINGHE
1
15 Jan 2014
IT-Ascoli Piceno-MAZZONI
1
11 Sep 2012
LU-Luxembourg-CHL
1
13 Feb 2014
SE-Vaxjo-VASTMANLAND
1
10 Dec 2013
NL-Amstelveen-AMSTELLAND
1
11 Sep 2012
NL-Geldrop-STANNA
1
20 Jun 2012
IT-Pesaro-SANSALVATORE
1
11 Jan 2012
IT-Civitanova Marche-AZURZONA
1
10 Jul 2012
CH-Geneve (14)-HCUGE
1
18 Dec 2012
NO-Bergen-HELSEBERGEN
27 Jun 2012
IT-Pavia-SANMATTEO
14 Dec 2011
NL-Dirksland-VANWEELBETHESDA
14 Dec 2011
NO-Levanger-HELSENORD
SE-Sundsvall-RVN
16 Oct 2012
IT-Prato-DOLCE
IT-Pozzuoli (Napoli)-LASCHIANA
IT-Potenza-OSPEDALESSANCARLO
IT-Roma-AGOSTINOGEMELLI
NO-Kristiansand-SORLANDET
11 Mar 2013
IT-Rieti-SANCAMILLODELELLIS
IT-San Giovanni Rotondo-SOLLIEVO
IT-Termini Imerese (PA)-SALVATORE
IT-Roma-TORVERGATA
NL-Amsterdam-AVL
IT-Taormina-SANVINCENZO
IT-Roma-SANTOSPIRITO
IT-Roma-REGINAMARGHERITA
TR-Ankara-GAZIUH
13 May 2013
IT-Treviso-FONCELLO
TR-Istanbul-ISTANBULUH
22 Aug 2013
TR-Izmir-EGEUH
22 Jan 2013
NO-Harstad-UNNHARSTAD
15 Jun 2012
AU-Sydney-CONCORD
31 Oct 2013
IT-Rimini-CERVESI
IT-Sassari-UDSSASSARI
IT-Parma-UDSPARMA
BE-Mons-AMBROISE
29 Jul 2011
SE-Helsingborg-SKANE
24 Aug 2012
IT-Asti-CARDINALMASSAIA
IT-Aviano-CROSANITA
IT-Bari-ONCOLOGICOBARI
08 Jun 2012
IT-Belluno-SANMARTINOB
IT-Benevento-GAETANORUMMO
IT-Torino-MOLINETTEG
11 Jan 2012
IT-Borgomanero-RIUNITITRINA
IT-Busto Arsizio (Varese)-VALLEOLONA
IT-Cagliari-BUSINCO
IT-Acquaviva delle Fonti (BA)-MIULLI
CH-Olten-KSO
07 Aug 2012
SE-Stockholm-KAROLINSKASOLNA
04 Jul 2012
NO-Lørenskog-AKERSHUS
11 Jul 2012
AT-Innsbruck-IMED
AT-Vienna-HANUSCH
FI-Turku-TYKS
27 Jan 2014
AU-Sydney-STGEORGE
11 Nov 2013
AT-Feldkirch-IKHF
AT-Vienna-AKHWEIN
AT-Wels-WEGR
BE-Baudour-EPICURABAUDOUR
NL-Tilburg-TWEESTEDEN
IT-Caltanissetta-ELIA
IT-Campobasso-SACROCUORE
IT-Milano-SANCARLOMI
IT-Monserrato-PRESIDIOPOLICLINICO
IT-Monza-SANGERARDO
IT-Napoli-SANGENNARO
IT-Nocera Inferiore (Solerno)-UMBERTON
IT-Novara-MAGGIORENOVARA
10 Oct 2011
IT-Orbassano-GONZAGA
06 Feb 2012
IT-Palermo-CERVELLO
IT-Palermo-MADDALENA
IT-Palermo-UNIPALERMO
IT-Milano-SANRAFFAELA
AU-Sydney-PRINCEOFWALES
16 Oct 2013
IT-Catanzaro-PUGLIESECIACCIO
08 May 2013
IT-Cesena-BUFALINI
IT-Cremona-CREMONESE
IT-Frosinone-ASLFROSINONE
IT-Ivrea-IVREA
IT-Latina-MARIAGORETTI
IT-Lecce-VITOFAZZI
IT-Mantova-CARLOPOMA
IT-Messina-AOPAPARDO
15 Jul 2011
IT-Milano-MAGGIOREPOLI
IT-Firenze-CAREGGI
= Active hospitals
= Inactive hospitals

Participating Parties

Downloads

Up