LLPC working group




Prof. M.J. Kersten (AmsterdamUMC – AMC, Amsterdam)


Prof. M.C. Minnema (UMCU, Utrecht)


Dr P. Mutsaers (ErasmusMC, Rotterdam)

Key objectives of working group

The key objectives of this working group are:

  • To contribute actively to the implementation of so-called “first-in-man” phase I-II studies in malignant diseases of the blood, bone marrow and lymph nodes, including, but not limited to Non-Hodgkin's lymphoma (B and T cell), Hodgkin's lymphoma and chronic lymphocytic leukemia (CLL). Promising new drugs can then be incorporated in phase III studies, which are executed by the HOVON Lymphoma and CLL Working Groups. This creates the perspective to operate in the front line in HOVON with regard to the treatment of lymphomas and CLL with innovative therapies.
  • By close collaboration, the turnaround time for deciding on studies, getting the protocol approved and enrolling the first patients is short.
  • For the time being, it is expected that trials performed in the context of HOVON/LLPC will mainly be industry-sponsored trials. Ultimately, the goal is also to develop investigator-initiated studies. The working group will assess the relevance and feasibility of each study offered through one of its members or by industry. If it is decided to participate in the study on behalf of HOVON/LLPC, it will be determined by mutual agreement how many and which centers will participate, making sure there is regional spread. Non-participating centers are committed to refer patients to participating centers for study opportunities.

The Lunenburg Lymphoma Phase 1 / II Consortium (LLPC) was founded in 2009 by 5 departments of Hematology of Dutch (academic) hospitals. Currently, the participating hospitals are:

  • AmsterdamUMC, locations AMC and VUMC, Amsterdam
  • Erasmus Medical Center (Erasmus MC), Rotterdam
  • University Medical Center Groningen (UMCG), Groningen
  • Radboud University Medical Center (RadboudUMC), Nijmegen
  • University Medical Center Utrecht (UMCU), Utrecht
  • Leiden University Medical Center (LUMC), Leiden
  • Maastricht University Medical Center (MUMC), Maastricht

Other centers can join the consortium if they are interested in and have the required facilities/dedicated study personnel to perform phase I/II studies.

Publication overview

Meetings & Minutes

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