HOVON HO70

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Main info

Identificatie:
HOVON 70 ALL
Sponsor:
HOVON
Included patients:
54
Active sites:
18
(of 20)
Title:

Feasibility study using repeated intensive chemotherapy courses for patients with primary acute lymphoblastic leukemia in adults age 18 - 39 years inclusive.

Timeline

Scheduled
Actual
2005
01 jan.
Opportunity
2005
21 okt.
Activated
2007
28 aug.
Closeout in Progress
2017
28 aug.
Archived

Flow

Flow

Details

Phase:
Prospective Phase II study
Monitoring Type:
Objectives:

Eligibility

Inclusion Criteria:
  • Age 18 - 39 years inclusive;
  • Primary previously untreated ALL (including Philadelphia chromosome or BCR-ABL positive ALL);
  • WHO performance status 0, 1, or 2 (appendix C);
  • Negative pregnancy test at inclusion if applicable;
  • Written informed consent.
Exclusion Criteria:
  • Mature B-cell ALL;
  • Acute undifferentiated leukemia;
  • Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease);
  • Severe pulmonary dysfunction (CTCAE grade III-IV, see appendix D);
  • Severe neurological or psychiatric disease;
  • Significant hepatic dysfunction (serum bilirubin or transaminases >=3 times normal level);
  • Significant renal dysfunction (serum creatinine >= 3 times normal level);
  • History of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma;
  • Active, uncontrolled infections;
  • Patients known to be HIV-positive;
  • Patient is a lactating woman;
  • Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule.

Participating Sites

Site
18 results
Order by
Accrual rate
Activation date
NL-Amsterdam-VUMC
9
NL-Amsterdam-AMC
9
NL-Rotterdam-EMCDANIEL
7
NL-Groningen-UMCG
6
NL-Nieuwegein-ANTONIUS
5
NL-Rotterdam-ERASMUSMC
3
NL-Nijmegen-RADBOUDUMC
3
NL-Arnhem-RIJNSTATE
2
BE-Leuven-UZLEUVEN
2
NL-Den Haag-HAGA
1
NL-Leiden-LUMC
1
BE-Roeselare-AZDELTA
1
NL-Amersfoort-MEANDERMC
1
NL-Maastricht-MUMC
NL-Den Bosch-JBZ
NL-Zwolle-ISALA
BE-Antwerpen-ZNASTUIVENBERG
BE-Brugge-AZBRUGGE
= Active hospitals
= Inactive hospitals

Participating Parties

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