HOVON HO70

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Main info

Identificatie:
HOVON 70 ALL
Sponsor:
HOVON
Included patients:
54
Active sites:
18
(of 20)
Title:

Feasibility study using repeated intensive chemotherapy courses for patients with primary acute lymphoblastic leukemia in adults age 18 - 39 years inclusive.

Timeline

Scheduled
Actual
2005
01 jan.
Opportunity
2005
21 okt.
Activated
2007
28 aug.
Closeout in Progress
2015
13 okt.
Archived
2030
13 okt.
Destruction

Flow

Flow

Details

Phase:
Prospective Phase II study
Monitoring Type:
Objectives:

Eligibility

Inclusion Criteria:
  • Age 18 - 39 years inclusive;
  • Primary previously untreated ALL (including Philadelphia chromosome or BCR-ABL positive ALL);
  • WHO performance status 0, 1, or 2 (appendix C);
  • Negative pregnancy test at inclusion if applicable;
  • Written informed consent.
Exclusion Criteria:
  • Mature B-cell ALL;
  • Acute undifferentiated leukemia;
  • Severe cardiovascular disease (arrhythmias requiring chronic treatment, congestive heart failure or symptomatic ischemic heart disease);
  • Severe pulmonary dysfunction (CTCAE grade III-IV, see appendix D);
  • Severe neurological or psychiatric disease;
  • Significant hepatic dysfunction (serum bilirubin or transaminases >=3 times normal level);
  • Significant renal dysfunction (serum creatinine >= 3 times normal level);
  • History of active malignancy during the past 5 years with the exception of basal carcinoma of the skin or stage 0 cervical carcinoma;
  • Active, uncontrolled infections;
  • Patients known to be HIV-positive;
  • Patient is a lactating woman;
  • Any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and follow-up schedule.

Participating Sites

Site
18 results
Order by
Accrual rate
Activation date
NL-Amsterdam-AMC
9
NL-Amsterdam-VUMC
9
NL-Rotterdam-EMCDANIEL
7
NL-Groningen-UMCG
6
NL-Nieuwegein-ANTONIUS
5
NL-Rotterdam-ERASMUSMC
3
NL-Nijmegen-RADBOUDUMC
3
BE-Leuven-UZLEUVEN
2
NL-Arnhem-RIJNSTATE
2
BE-Roeselare-AZDELTA
1
NL-Amersfoort-MEANDERMC
1
NL-Leiden-LUMC
1
NL-Den Haag-HAGA
1
NL-Maastricht-MUMC
NL-Den Bosch-JBZ
NL-Zwolle-ISALA
BE-Antwerpen-ZNASTUIVENBERG
BE-Brugge-AZBRUGGE
= Active hospitals
= Inactive hospitals

Participating Parties

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